Comparative Study of Manual Stereotypies in Rett Syndrome and Autism –movement Quantification
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چکیده
Stereotypies are defined as involuntary movements, coordinated, repetitive, rhythmic, and with no specific objective. Autism and Rett Syndrome (RTT) have significant phenotypic overlap, and both are classified as pervasive developmental disorders. Hand stereotypies are common in both pathologies. Our aim is to determine quantitatively if they are really different as they seem to be by single observation. In order to characterize quantitatively stereotypic movements we designed a study based on 2d video capture and kinematic analysis. We determine the velocity, the frequency, the displacement, the extent, the duration and the number of stereotypies in both pathologies, RTT and Autism, in a population of 9 patients 4 with RTT with MECP2 mutation and 5 with Autism. The stereotypies of Autism, are faster, more repetitive, more extent and with a higher displacement, they also last less time and occurs less often than the stereotypies of RTT.
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